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A Natural History Study of Metabolic Sizing in Health and Disease

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT05398783

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 2–99 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
2000
US sites recruiting
1
Study start
October 25, 2022
Record last updated
October 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Background

Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate. But metabolism varies among people with similar body sizes. Scientists now believe the old formulas for estimating metabolic rates may not work well for all people. Researchers want to find more accurate ways to measure a person s metabolism.

Objective

This natural history study will examine the relationships between metabolism, body composition, and body surface area in a wide range of people.

Eligibility

Healthy children and adults aged 2 years or older. Also, people aged 2 years or older with conditions that may alter metabolism. These may include diabetes, obesity, renal disease, or cancer.

Design

Participants will spend 2 days and 1 night in the hospital. They will provide a medical history and answer questions about their activity levels, the foods they eat, and their lifestyle. They will also eat a special diet.

Participants will undergo many tests

They will lie in a bed with a clear hood covering their head for 30 to 45 minutes to measure the gases in their breath.

They will lie on a padded table for about 15 minutes while their body is scanned.

They will stand on a platform while a 3D scanner measures their body.

They will have a test to measure how fast an electric signal moves through their body.

They will grip an instrument to measure the strength of their hands.

They will drink salty water and provide blood and urine samples.

Participants may be invited to return for these 2-day visits up to 8 times per year. Return visits must be at least 2 weeks apart.

Conditions: Metabolic Disorders; Cancer; Chronic Kidney Disease; Diabetes; Normal Physiology

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria
  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all the following criteria for their cohort:

Cohort 1 - Healthy Volunteers

  • Male or female, aged >=2 years
  • In good general health as evidenced by medical history

Cohort 2 - Patients

  • Male or female, aged >=2 years
  • Diagnosed with diseases thought to alter metabolism or body composition (such as weight loss or gain, diabetes, renal disease, obesity, cancer, etc.) or taking medications thought to alter metabolism or body composition.

EXCLUSION CRITERIA

An individual who meets any of the following criteria will be excluded from participation in this study:

  • Participants over 200 kg due to the weight limit of the equipment.
  • Presence of any implanted device that would interfere with measurements.
  • Any moderate to severe limitations in mobility that would impede participation
  • Hemoglobin less than 10 g/dL (in participants who would have blood drawn for research purposes).
  • Participants with dietary allergies, intolerances or eating patterns that would preclude them from consuming metabolic meals.
  • Participants unwilling or unable to give informed consent.
  • Participants with any other significant physical, medical, or psychiatric limitations, illness or conditions that may preclude them from completing the majority of the tests in this study per the discretion of the PI.

Recruiting US locations

  • National Institutes of Health Clinical Center

    Bethesda, MD 20892

    Site contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) · 800-411-1222 · ccopr@nih.gov

Study contacts (from the official record)

  • Margaret S McGehee, C.R.N.P. · (301) 594-6799 · mcgeheems@mail.nih.gov
  • Kong Y Chen, Ph.D. · (301) 451-1636 · chenkong@niddk.nih.gov
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A Natural History Study of Metabolic Sizing in Health and Disease (NCT05398783) | Bored Studies