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A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

Arizona State University · with Banner Alzheimer's Institute · NCT05877196

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
216
US sites recruiting
1
Study start
June 22, 2023
Record last updated
May 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are:

  • test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes;
  • identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and
  • examines the mechanisms of aerobic exercise's action on memory in older adults with early AD.

Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.

Being studied: Moderate Intensity Continuous Training (MICT); Chair-based Stretch; High-Intensity Interval Training (HIIT); Combined Aerobic Resistance Exercise (CARE)

Conditions: Mild Cognitive Impairment; Alzheimer Disease; Cognitive Impairment; Cognitive Decline; Memory Loss; Memory Impairment

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Participants

  • Clinical diagnosis of MCI or probable and possible mild AD dementia according to 2011 Alzheimer's association-NIA criteria.
  • Community-dwelling, e.g., homes and assisted living
  • Age 65 years and older
  • Medical clearance from PCP or cardiovascular provider
  • Have a qualified study partner
  • Agree to the blood draws
  • Verified MRI safety

Study Partner

  • Age 18 or older
  • Contact with participant ≥ 2 times per week for ≥ 6 months
  • Know the participant's memory status and ability to perform activities of daily living
  • Consent to participant

Exclusion Criteria

Participants

  • Resting HR ≤ 50 or ≥ 100 beats/min after 5-minutes of quiet resting
  • American College of Sports Medicine contraindications to exercise
  • New, unevaluated symptoms or diseases a healthcare provider has not evaluated
  • Abnormal cardiac condition uncovered during VO2peak testing
  • Enrollment in another intervention that aims at improving cognition
  • Moderate to strenuous exercise ≥150 minutes a week in the previous 6 months
  • ≥ 2 anti-depression medications, or poorly managed or unstable depression
  • Poorly managed or unstable anxiety

Study partners

  • none

Recruiting US locations

  • Arizona State University

    Phoenix, AZ 85004

    Site contact: Kristi Spieleder, MS · 480-884-2765 · kspieled@asu.edu

Study contacts (from the official record)

  • Kristi Spieleder, MS · 480-884-2765 · kspieled@asu.edu
All neurology studies in Arizona →
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness… (NCT05877196) | Bored Studies