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RecruitingAccepts healthy volunteersPhase 1

A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease

Eli Lilly and Company · NCT07787182

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
68
US sites recruiting
1
Study start
October 14, 2025
Record last updated
October 22, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to see how safe LY4405094 is and to see how much and how quickly LY4405094 gets into the bloodstream. For healthy participants, the study also looks at how much LY4405094 gets into the fluid around the brain and lasts up to 13 weeks and will include a 4-day stay in the Clinical Research Unit (CRU). For participants with Alzheimer's Disease, the study will also look at levels of a specific Alzheimer's-related protein in the brain and will last up to 25 weeks and will include a 3-day stay in the CRU.

Being studied: LY4405094; LY4405094; Placebo; Placebo; Florbetapir F18; Florbetaben F 18

Conditions: Healthy Volunteers; Alzheimer Disease; Amyloid; Plaque, Amyloid

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants must meet eligibility criteria in the ATMP screening protocol before entry into the treatment study.

Exclusion Criteria

  • Have known allergies to LY4405094, related compounds (including remternetug), or any components of the formulation, including LY4405094.
  • Have known allergic reactions to adhesive or hydrogels or a family history of adhesive skin allergies.

Recruiting US locations

Study contacts (from the official record)

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 1-317-615-4559 · LillyTrials@Lilly.com
  • Physicians interested in becoming principal investigators please contact · clinical_inquiry_hub@lilly.com
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A Study of LY4405094 in Healthy Participants and Participants With… (NCT07787182) | Bored Studies