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RecruitingAccepts healthy volunteersPhase 1

A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years

Centessa Pharmaceuticals (UK) Limited · NCT07413666

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–60 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
212
US sites recruiting
1
Study start
February 25, 2026
Record last updated
February 25, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Characterize the safety, tolerability and pharmacokinetics of ORX489 following single and multiple doses.

Being studied: ORX489 Tablets; Placebo Tablets

Conditions: Healthy Adult Male and Female Volunteers

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy males or females as determined by assessments at the Screening Visit.
  • For Parts A, B, C, and D: Participants must be at least 18 years of age and no more than 60 years of age at the Screening

Exclusion Criteria

  • Presence of significant cardiac, pulmonary, gastrointestinal, hepatic, renal, hematological, malignancy, endocrine, neurological, or psychiatric disease, as determined by medical history, physical examination, and screening investigations.
  • History of seizure disorder, any other condition that increases the risk of seizure
  • Has a clinically significant sleep disorder, including insomnia or sleep apnea

Recruiting US locations

Study contacts (from the official record)

  • ORX489 Centessa Program Lead ORX489 Centessa Program Lead · 617-468-5770 · ORX489-101study@centessa.com
  • Celerion Program Lead CA49982 United States, Nebraska [Recruiting]
All healthy volunteers studies in Nebraska →
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years (NCT07413666) | Bored Studies