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A Study of the Jovi Patch, Powered by Signal Relief, for the Improvement of General Menstrual Discomfort

Signal Relief · with Holy Redeemer Hospital · NCT07825558

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · Women only
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Not applicable
Target enrollment
50
US sites recruiting
1
Study start
May 8, 2026
Record last updated
September 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This pilot study is testing whether a thin, flexible, drug-free patch called the Jovi Patch (powered by Signal Relief) can help reduce general menstrual discomfort (pain and related symptoms during periods).

The patch contains no medication, wires, or batteries. It uses special micro-metal particles that are thought to interact with the body's natural electrical signals related to pain. Researchers will compare an active version of the patch to a look-alike sham (inactive) patch.

About 50 pre-menopausal women ages 18-50 who have menstrual discomfort (pain score greater than 4 on a 0-10 scale) will be randomly assigned to one of two groups:

Active patch group (larger group) Sham patch group

Participants will wear their assigned patch during six menstrual cycles (starting the day before their period begins and continuing through the week of flow). After three cycles, women in the sham group will switch to the active patch for the remaining three cycles so researchers can also look at the effects of switching.

The main question is whether more women using the active patch achieve at least a 30% reduction in their pain scores compared with those using the sham patch. The study will also track changes in how much menstrual symptoms interfere with daily life, use of pain medications, and any side effects (such as skin irritation).

Participation lasts through six menstrual cycles. The overall study is expected to take up to 12 months.

Being studied: Jovi Patch; Sham Patch

Conditions: General Menstrual Discomfort

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Pre-menopausal female subjects aged 18 -50 years.
  • Currently seeking treatment for general menstrual discomfort
  • NPRS scale score > 4 at baseline.
  • Able and willing to provide informed consent in English without the assistance of an interpreter.

Exclusion Criteria

  • Receiving other investigational agents or on another clinical trial.
  • Subject has implantable pain device, pacemaker, defibrillator, or other neuromodulation implantable device.
  • Known to be pregnant, or plan to become pregnant in the next 6 months
  • Current Jovi/Signal Relief users

Recruiting US locations

  • Redeemer Health

    Meadowbrook, PA 19046

    Site contact: Ashley Trymbiski · 4452008090 · atrymbiski@gmail.com

Study contacts (from the official record)

  • Ashley Trymbiski · 4452008090 · atrymbiski@gmail.com
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