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A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors

Medical College of Wisconsin · NCT05023434

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
20
US sites recruiting
1
Study start
April 17, 2023
Record last updated
October 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much tumor as possible without a resultant permanent neurological deficit. However, the subjective nature of current intraoperative hand motor assessments do not offer a comprehensive understanding of how hand strength and function may be impacted by resection. Additionally, there is a paucity of data to inform how altering DES parameters may effect motor mapping. Here, the investigators seek to demonstrate a feasible, standardized protocol to quantitatively assess hand strength and function and systematically assess several stimulation parameters to improve intraoperative measurements and better understand how cortical stimulation interacts with underlying neural function.

Being studied: Intraoperative Brain Simulation - Alternate Stimulation Parameters

Conditions: Brain Tumor; Brain Cancer; Motor Cortex; Lesion

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

AWAKE CRANIOTOMY COHORT

Inclusion Criteria

  • Age 18 - 75
  • Ability to understand a written informed consent document, and the willingness to sign it
  • Radiographic evidence of tumor on MRI (i.e. non-enhancing) invading primary motor cortex in the non-dominant hemisphere.
  • Karnofsky performance status (KPS) ≥ 70
  • Normal or near normal motor strength (i.e., at least 3/5 in relevant areas)
  • Normal or near normal speech (Can consistently name at least 4/5 cards)
  • Free of other illness, in the judgment of the investigator, that may shorten life expectancy
  • Willing and able to participate in all aspects of the study

Exclusion Criteria

  • Presence of other malignancy not in remission
  • Evidence of bi-hemispheric or widespread tumor involvement
  • Medically high-risk surgical candidate
  • History of recent scalp or systemic infection
  • Presence of other implants or foreign bodies in the head
  • Inability to receive an MRI for any reason
  • Inability to receive cortical stimulation for any reason
  • Presence of implanted cardiac device (such as a pacemaker or defibrillator)

Recruiting US locations

  • Medical College of Wisconsin

    Milwaukee, WI 53226

    Site contact: Sarah Cornell · 4149550989 · scornell@mcw.edu

Study contacts (from the official record)

  • Kaitlin Goetschel · 414-955-7398 · kgoetschel@mcw.edu
All healthy volunteers studies in Wisconsin →
A Study to Measure the Effect of Brain Stimulation on Hand… (NCT05023434) | Bored Studies