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Acute Effects of THC in Older Adult

Yale University · with National Institute on Drug Abuse (NIDA) · NCT06948136

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
60
US sites recruiting
1
Study start
June 6, 2025
Record last updated
October 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults > 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm [P300], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.

Being studied: Delta-9-THC Low Dose; Placebo; Delta-9-THC Medium Dose

Conditions: Age-related Cognitive Decline

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria
  • Ability to provide informed consent
  • No history (current or past) of unstable or serious medical, neurological or psychiatric conditions.
  • High school education or greater
  • No positive pregnancy test and/or lactation/ planning to nurse while in this study
  • English speaking

Recruiting US locations

  • VA Connecticut Healthcare System

    West Haven, CT 06516

    Site contact: Khaled Draghmeh, MD · 203-932-5711 · khaled.draghmeh@yale.edu

Study contacts (from the official record)

  • Khaled Draghmeh, MD · 203-932-5711 · khaled.draghmeh@yale.edu
  • Ashley Schnakenberg Martin, PhD · ashley.martin@yale.edu
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Acute Effects of THC in Older Adult (NCT06948136) | Bored Studies