Aging, Geriatric Syndromes and Clonal Hematopoiesis

Inclusion Criteria

• At least 50 years of age.
• Able to understand written and spoken English.
• Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)

Exclusion Criteria

• Inability or unwillingness to complete health questionnaire (with the exception of hip and knee replacement participants).
• History of a recent (\<30 days) acute viral illness.
• Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy > 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.
• Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.
• Vulnerable populations (e.g. prisoners).
• Known infection with Hepatitis B or C, HTLV, or HIV.
• Additional exclusion for optional bone marrow aspirate/biopsy substudy:

• Use of medications for anticoagulation or "blood thinning" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)
• allergy to lidocaine or other local anesthetics.