Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Alveolar Macrophage Programming Following Endotoxin Exposure

National Jewish Health · NCT03859050

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
25
US sites recruiting
1
Study start
March 18, 2019
Record last updated
May 6, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The histologic hallmarks of lung inflammation include accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).

Being studied: bronchoscopy with intrabronchial administration of lipopolysaccharide

Conditions: ARDS, Human

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Written, informed consent
  • Age 18-50

Exclusion Criteria

  • Current or recent illness (past 2 weeks)
  • Presence or prior history of cardiac, pulmonary or systemic disease
  • Bleeding disorder, use of systemic anticoagulants or antiplatelet therapy
  • American Society of Anesthesiology (ASA) class 2 or greater
  • Immunocompromised state (HIV, immunoglobulin deficiency, systemic immunosuppressants)
  • Use of any inhaled substance, including tobacco, marijuana, e-cigarrettes, cocaine, methamphetamines, or toxic vapors in the past 3 months or greater than 10 pack-year smoking history
  • Alcohol use disorder or greater than 7 drinks/week for women or greater than 14 drinks/week for men in the past 3 months
  • Allergy or prior adverse reaction to lidocaine, midazolam or fentanyl
  • Abnormal spirometry or electrocardiogram at time of screening
  • Pregnant (based on urine pregnancy test) or breast feeding

Recruiting US locations

  • National Jewish Health

    Denver, CO 80206

    Site contact: Kara Mould · 303-398-1787

Study contacts (from the official record)

  • Kara Mould · 303-398-1787 · mouldk@njhealth.org
All healthy volunteers studies in Colorado →
Alveolar Macrophage Programming Following Endotoxin Exposure (NCT03859050) | Bored Studies