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Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

University of Minnesota · NCT04439370

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 35–70 · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
160
US sites recruiting
1
Study start
October 1, 2019
Record last updated
January 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Being studied: Microneurography to measure muscle sympathetic nerve activity (MSNA); Baroreflex sensitivity testing; Sympathoexcitatory Maneuvers; Blood tests

Conditions: Hypertension; Menopause, Premature; Menopause; Blood Pressure

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause
  • Premenopausal 35-49 years of age
  • Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
  • Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of >30 mIU/mL

Exclusion Criteria

  • Current nicotine/tobacco use within the past six months
  • Are diabetic or asthmatic
  • Have diagnosed significant carotid stenosis
  • Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury.
  • Have existing metabolic or endocrine abnormities
  • Take any heart/blood pressure medications that are determined to interfere with study outcomes
  • IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
  • Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
  • Are pregnant or breastfeeding

Recruiting US locations

  • University of Minnesota

    Minneapolis, MN 55455

    Site contact: Manda Keller-Ross, PhD, DPT, PT · 612-625-3175 · kell0529@umn.edu

Study contacts (from the official record)

  • Manda Keller-Ross, PhD, DPT, PT · 612-625-3175 · kell0529@umn.edu
All heart & blood pressure studies in Minnesota →
Autonomic Regulation of Blood Pressure in Premature and Early… (NCT04439370) | Bored Studies