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Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

UConn Health · NCT07083531

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50+ · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
50
US sites recruiting
1
Study start
August 23, 2022
Record last updated
July 24, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.

Being studied: Healthy volunteers without SCT; Healthy volunteers with SCT

Conditions: Sickle Cell Disease; Sickle Cell Trait

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Female of African Decent.
  • Age 50 years or older.
  • Lack of menstrual period for at least 12 consecutive months

Exclusion Criteria

  • Taking medications known to influence bone metabolism (e.g., glucocorticoids, hormonal therapy, cancer or chemotherapy meds, anti-resorptive medications or anabolic therapies).
  • Known metabolic bone disorder (e.g., uncontrolled thyroid disease, hyperparathyroidism, Vitamin D deficiency)
  • Taking an investigational drug
  • Documented sickle cell disease

Recruiting US locations

  • UConn Health

    Farmington, CT 06030

    Site contact: Sasia Jones, MPH · 860.679.7879 · Sajones@uchc.edu

Study contacts (from the official record)

  • Zoe Green, BS · 860.679.4656 · zgreen@uchc.edu
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Bone Loss, Physical Function and Frailty in Older Women With… (NCT07083531) | Bored Studies