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RecruitingAccepts healthy volunteersPhase 2

Brain Blood Vessel Responses to Changes in Blood Flow

University of Wisconsin, Madison · with National Institute of Neurological Disorders and Stroke (NINDS) · NCT06629077

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 55–69 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
36
US sites recruiting
1
Study start
February 26, 2026
Record last updated
September 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

Being studied: MRI; Prazosin; Placebo

Conditions: Magnetic Resonance Imaging; Cerebrovascular Circulation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Between the ages of 55-69 years
  • Have a BMI less than or equal to 34.5 kg/m2
  • Nonsmoker
  • are less than 72 in (182.88 cm) height
  • Females must be postmenopausal

Exclusion Criteria

  • Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
  • History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
  • History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
  • Uncontrolled hypertension
  • History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
  • Severe untreated obstructive sleep apnea
  • History of diabetes with HbA1c greater than 9.5%
  • Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
  • Current or recent (\<1 year) major psychiatric condition (Axis I) or addictive disorders
  • Significant surgical history
  • Other significant medical conditions at investigators' discretion
  • Contraindications to MRI
  • Prescribed medications that interfere with prazosin
  • Lactose allergy
  • lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI).

Recruiting US locations

  • University of Wisconsin

    Madison, WI 53705

    Site contact: Anna J Howery, MS · 608-262-9572 · barneslab@education.wisc.edu

Study contacts (from the official record)

  • Anna Howery · 608-262-9572 · ahowery@wisc.edu
All healthy volunteers studies in Wisconsin →
Brain Blood Vessel Responses to Changes in Blood Flow (NCT06629077) | Bored Studies