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RecruitingAccepts healthy volunteersPhase 2

Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort

University of Wisconsin, Madison · NCT06629090

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 20–40 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
36
US sites recruiting
1
Study start
December 17, 2025
Record last updated
July 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

Being studied: MRI; Prazosin; Placebo

Conditions: Magnetic Resonance Imaging; Cerebrovascular Circulation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Between the ages of 20-40 years
  • Have a BMI ≤34.5 kg/m2
  • are less than 72 in (182.88 cm) height
  • Nonsmoker

Exclusion Criteria

  • Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
  • History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
  • History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
  • Uncontrolled hypertension
  • History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
  • Severe untreated obstructive sleep apnea
  • History of diabetes with HbA1c greater than 9.5 percent
  • Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
  • Current or recent (less than1 year) major psychiatric condition (Axis I) or addictive disorders
  • Significant surgical history
  • Other significant medical conditions at investigators' discretion
  • Contraindications to MRI
  • Prescribed medications that interfere with prazosin
  • Lactose allergy
  • lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI)

Recruiting US locations

  • University of Wisconsin

    Madison, WI 53705

    Site contact: Anna J Howery, MS · 608-262-9572 · barneslab@education.wisc.edu

Study contacts (from the official record)

  • Anna Howery · 608-262-9572 · ahowery@wisc.edu
All healthy volunteers studies in Wisconsin →
Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort (NCT06629090) | Bored Studies