Brain Connections for Arm Movement After Stroke

Inclusion Criteria

Inclusion Criteria (control participants):

• Be 45-90 years of age
• Have adequate language and neurocognitive function to participate in training and testing
• Be medically stable to participate in the study
• Be English speaking

Inclusion Criteria (participants with stroke):

• Be 45-90 years of age
• Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
• Stroke onset at least 6 months before enrollment
• Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
• Present with mild to moderate arm dysfunction
• Be medically stable to participate in the study
• Be English speaking

Exclusion Criteria

(for both groups)

• Unable to give informed consent
• Have a serious complicating medical illness that would preclude participation
• Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
• Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
• Unable to comply with requirements of the study
• Enrollment in another greater-than-minimal risk study
• Presence of medical condition or implant that prevents safe administration of TMS or MRI
• Pregnancy