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Brain Health in Transgender Adults

University of Wisconsin, Madison · NCT07624747

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
72
US sites recruiting
1
Study start
October 14, 2025
Record last updated
June 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to test whether and how a person's brain changes in the first few months after starting gender affirming hormone therapy (GAHT). The investigators want to know if GAHT changes: 1) cerebral blood flow (CBF), 2) brain structure, connectivity, and cognitive task performance, and 3) neurocognitive function (memory, attention, executive function, processing speed). 36 male at birth and 36 female at birth participants will conduct baseline studies prior to GAHT, with a second identical set of study visits 4-6 months after GAHT begins.

Being studied: Magnetic Resonance Imaging; Cognition and Health Tests; Optional Exercise Test

Conditions: Gender Dysphoria

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • intention to undergo GAHT

Exclusion Criteria

  • BMI greater than 40 kg/m2
  • Age greater than 45 yrs
  • Blood pressure greater than 140/90 (stage II hypertension)
  • A current diagnosis of type II diabetes
  • History of traumatic brain injury/concussion, stroke, or seizures
  • Are post-menopausal
  • Previously taken hormone therapy medications
  • Self-reported pregnancy (no pregnancy test)

Recruiting US locations

  • UW School of Medicine and Public Health

    Madison, WI 53792

Study contacts (from the official record)

  • Shawn Bolin, MS · 608-263-6308 · sbolin@wisc.edu
All healthy volunteers studies in Wisconsin →
Brain Health in Transgender Adults (NCT07624747) | Bored Studies