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RecruitingAccepts healthy volunteersPhase 3

Building Adaptive School-based Interventions for Caries

University of Pennsylvania · with National Institute on Minority Health and Health Disparities (NIMHD) · NCT07265830

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 5–13 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 3
Target enrollment
1200
US sites recruiting
1
Study start
August 18, 2026
Record last updated
September 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Dental caries (tooth decay) is the world's most prevalent noncommunicable disease. Current preventive and therapeutic treatments are available that can be provided in a school-based health service environment. However, not all children respond to care, and school programs can result in under- or over-treatment, leaving children at high risk. The Building Adaptive School-based Interventions for Caries (BASICS) study will identify the optimal sequence and intensity of these treatments to minimize nonresponse, creating adaptive interventions tailored to specific needs in order to personalize school-based dental medicine.

Being studied: Silver Diamine Fluoride (38%); Glass Ionomer Sealant; Fluoride Varnishes; Hygiene Intervention

Conditions: Dental Caries

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Be enrolled in participating schools
  • Be between the ages of 5 and 13 years
  • Provide parental/guardian informed consent
  • Child assent

Exclusion Criteria

  • Ulcerative gingivitis or stomatitis
  • Known sensitivity to silver or other heavy-metal ions
  • More than six affected sites
  • Those who have had full mouth gingivectomies
  • Patients showing abnormal skin sensitization in daily circumstances
  • Those who have had pulp capping

Recruiting US locations

Study contacts (from the official record)

  • Ryan R Ruff, PhD, MPH · 212-998-9663 · ryan.ruff@nyu.edu
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Building Adaptive School-based Interventions for Caries (NCT07265830) | Bored Studies