C-Protein in Fatigue and Aging

Inclusion Criteria

• Adults between the ages 18-35 or 65-80 years
• Healthy by self-report
• Willing to participate in all aspects of the study design including muscle biopsy, unilateral exercise, and physical activity monitoring
• Fluent in English (due to lack of translation services, it is not practical to conduct the study using a language other than English).

Exclusion Criteria

• Orthopaedic limitation (severe knee osteoarthritis, prior joint replacement, etc.).
• Volunteer has dementia or related mental issues that potentially put the subject at risk as determined by prior diagnosis.
• Volunteer has known untreated endocrine disease (hypo/hyper thyroidism, Addison's Disease or Cushing's syndrome, etc.)
• Volunteer has untreated/poorly-controlled hypertension (stage 2, per American College of Cardiology [>140/90 mmHg]).
• Volunteer has significant heart, liver, kidney or respiratory disease.
• Volunteer has diabetes (insulin dependent or non-insulin dependent).
• Volunteer has known coagulopathies.
• Volunteer has taken anabolic steroids in the prior six months.
• Volunteer has received treatment for cancer (other than effective Mohs Surgery for successful removal of basal cell or squamous cell carcinomas)
• Unexpected weight loss >5kg is last 12 months
• Volunteer is an active smoker or quit within the last year.
• Volunteer has known current alcohol or drug use disorder (AUD; defined as binge drinking of >4 days in the last month. Binge drinking is >5 drinks for men and >4 drinks for women, per occasion). Or, if a volunteer reports drinking in excess of "low risk" per NIAAA (>7 drinks/week for men and >3 drinks/day for women and >14 drinks/week and >4 drinks/day).
• Volunteer has a diagnosed neuromuscular disorder.
• Volunteer has allergy to lidocaine.