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Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 4

L. Cinnamon Bidwell · with National Institute on Drug Abuse (NIDA) · NCT07679581

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–40 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
64
US sites recruiting
1
Study start
December 10, 2025
Record last updated
July 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of two different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.

Being studied: Cannabis (smoked flower)

Conditions: Cannabis; Memory; Electroencephalography

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria
  • Must be between the ages of 21 and 40 and provide informed consent;
  • Must be right-handed (Laterality Quotient > 60 on Edinburgh Handedness Inventory - Short Form136);
  • Heavy users (HU) in Experiments 1, 2, 3, and 4:
  • Must use cannabis at least 4 days during the month;
  • Must be a cannabis user for at least a year;
  • Non-users (NU) in Experiment 2:
  • Must not have used cannabis for prior 6 months;
  • Must have at least one episode of lifetime cannabis use;
  • Must self-report not using other illicit recreational drugs (e.g., cocaine, benzodiazepines (non-prescription), opiates (non-prescription), MDMA, sedatives, or methamphetamine) in the past 30 days, during the Pre-Screening;
  • Must not test positive on a urine toxicology test for drugs of abuse at the Baseline Appointment (TDS);
  • Must not be using psychotropic medications, however anti-depressant, non-benzodiazepine anti-anxiety, and ADHD medications are ok. ADHD medication users must be willing to abstain from ADHD medication use on appointment days; ADHD medications, even extended-release forms, are short acting and medication" holidays" (e.g., on weekends and holidays) are routine in individuals prescribed ADHD medications, without adverse effects.
  • Must not be a regular nicotine user (≤4 days per week; cigarette, E-cigs, or smokeless);
  • Must not have used caffeine or nicotine (cigarette, E-cigs, or smokeless) for 4 hours;
  • Must have a breath alcohol level of 0 at screening (to sign consent form);
  • Must not be actively seeking or in treatment for any substance use disorder (drug use levels will be carefully monitored via Timeline Follow Back (TLFB) throughout the study to assess any confounding influences of drug or alcohol use;
  • Female subjects must not be or trying to become pregnant (as indicated by a pregnancy test \& screening form administered at Baseline);
  • Must not be in treatment for psychotic disorder or bipolar disorder; or have a history with these disorders;
  • Must not have any physical characteristics (e.g., thick hair, head size exceeding the limit of the net, dyed hair) or experience any technical difficulties during testing that result in a poor-quality EEG recording.
  • Participants in Experiment 4 a. Must not have participated in Experiment 3

Recruiting US locations

  • Center for Innovation and Creativity (CINC)

    Boulder, CO 80301

    Site contact: Katie N Paulich, Ph.D. · 303-492-9549 · cobra.custudy@gmail.com

Study contacts (from the official record)

  • Katie N Paulich, Ph.D. · 303-492-9549 · cobra.custudy@gmail.com
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Cannabis Observations on Brain Waves, Retrieval, and Attention:… (NCT07679581) | Bored Studies