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Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury

Kessler Foundation · NCT06841198

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
15
US sites recruiting
1
Study start
April 1, 2025
Record last updated
July 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect blood pressure.

The main questions are

How does stimulation affect blood pressure over the year? What is the level of cardiovascular activation throughout the year?

The study will start during the inpatient stay at the Kessler Institute for Rehabilitation and continue after discharge as an outpatient, totaling about 20-29 sessions over the year.

Being studied: spinal cord transcutaneous stimulation; Ice testing

Conditions: Spinal Cord Injuries (SCI); Orthostatic Hypotension, Dysautonomic; Cardiovascular; Transcutaneous Spinal Stimulation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

For the main study

Inclusion Criteria

  • Individuals with a spinal cord injury undergoing inpatient rehabilitation at the Kessler Institute for Rehabilitation
  • Between 18-75 years old
  • 7-50 days after injury
  • Injury level ≥ T6 (a cervical or a high-level chest injury)
  • Individuals experiencing low blood pressure after the injury
  • American Spinal Injury Association Impairment Scale (AIS) A or B

Exclusion Criteria

  • A ventilator is needed for breathing.
  • Devices such as brain/spine/nerve stimulators, a cardiac pacemaker/defibrillator, or intra-cardiac lines are present in the body.
  • There is a significant disease affecting the blood vessels or signals in the heart, or a recent heart attack (myocardial infarction) has occurred.
  • A new medication has been prescribed to treat blood pressure or a heart problem within the last five days (excluding midodrine).
  • There is a known infection in the body (e.g., urinary tract infection) or a current illness (e.g., recent diagnosis of deep vein thrombosis (DVT) or other blood clotting issues, and/or a pressure injury that might interfere with the study).
  • There is a history of seizures.
  • Pregnancy.

For the spin-off study ice-water vs ice-wrap test (see description in study arms):

____________________________________________________

Inclusion

Age 18-75.

Inclusion for individuals with SCI

  • Injury sustained more than 6 months ago
  • Injury level ≥ T6 (a cervical or a high-level chest injury)
  • American spinal injury association impairment scale (AIS) A - D

Exclusion

Foot lesions, uses a ventilator, devices such as brain/spine/nerve stimulators, significant or recent cardiovascular disease, known infection in the body

Recruiting US locations

Study contacts (from the official record)

  • Leighann Martinez, BA · (973)324-3557 · lmartinez@kesslerfoundation.org
All healthy volunteers studies in New Jersey →
Cardiovascular Function and Response to Stimulation Within the… (NCT06841198) | Bored Studies