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Cerebellar Involvement in Cognitive Sequencing

Johns Hopkins University · with National Institute of Mental Health (NIMH) · NCT06108336

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
50
US sites recruiting
1
Study start
March 1, 2024
Record last updated
September 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory that might account for both motor and cognitive contributions of the cerebellum is that the cerebellum is involved in sequencing of relevant events or stimuli. Previous experiments have suggested that disruption of the cerebellum impairs the prediction of the next event in a sequence. The present experiment will examine the impact of cerebellar stimulation on brain activation during the performance of both sequence-demanding and non-sequence-demanding tasks.

Being studied: TMS during sequence-demanding task; No TMS during sequence-demanding task; TMS during non-sequence-demanding task; No TMS during non-sequence-demanding task

Conditions: Effects of Cerebellar Stimulation on Brain Activation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 1) Age 18-50;
  • 2) educational attainment of at least 8 years;
  • 3) capable of giving informed consent;
  • 4) fluent speaker of English by self-report;
  • 5) right handed.

Exclusion Criteria

  • 1) illicit drug use within 30 days of MRI scanning;
  • 2) neurological or systemic disorder which can cause dementia or cognitive dysfunction;
  • 3) history of an Axis I psychiatric disorder including substance use disorder;
  • 4) history of definite stroke;
  • 5) focal lesion on MRI exam;
  • 6) uncorrected visual deficits by self-report
  • 7) contraindications for MRI scanning
  • 8) use of anxiolytic, antidepressant, neuroleptic, or sedative medication
  • 9) Additional exclusion criteria recommended by Wassermann for TMS neuromodulation, including: History of seizure or a family history of epilepsy, heart disease, intracardiac lines, increased intracranial pressure, history of head trauma, and history of respiratory disease

Recruiting US locations

  • Johns Hopkins University School of Medicine

    Baltimore, MD 21205

    Site contact: John E. Desmond, Ph.D.

Study contacts (from the official record)

  • John E Desmond, Ph.D. · 410-502-3583 · jdesmon2@jhmi.edu
  • JoAnna Mathena, MS · 443-571-0947 · labnim@jh.edu
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Cerebellar Involvement in Cognitive Sequencing (NCT06108336) | Bored Studies