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Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Mayo Clinic · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT04753996

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–85 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
300
US sites recruiting
1
Study start
March 8, 2021
Record last updated
February 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

Conditions: Primary Sclerosing Cholangitis; PSC; Cholangiocarcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

PSC

  • Patients diagnosed with PSC between the age of 18 and 85.
  • The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available.
  • Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included.

Controls

  • Controls without history of PSC or evidence of other chronic liver disease of either gender that will participate in this study should be between the ages of 18-85.

Exclusion Criteria

  • Patients unable to provide inform consent.
  • Prisoners and institutionalized individuals.
  • PSC with orthotopic liver transplantation
  • History of Roux En Y procedure

Recruiting US locations

  • Mayo Clinic in Rochester

    Rochester, MN 55905

    Site contact: Erik M Schlicht, B.A.,CCRP · 507-284-4312 · schlicht.erik@mayo.edu

Study contacts (from the official record)

  • Erik Schlicht, CCRP · (507) 284-4212 · schlicht.erik@mayo.edu
  • Jackie Bianchi · (507) 266-0346 · bianchi.jackie@mayo.edu
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Characterization of Biliary Cell-derived Organoids From Bile of… (NCT04753996) | Bored Studies