Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder

Inclusion Criteria

All

• Normal screening bloodwork.
• Adequate arterial access for placement of an arterial line and blood sampling per study protocol.

OUD Participants

• Diagnosis of opioid use disorder (OUD) according to DSM-5 criteria.
• Actively seeking treatment for OUD.
• Willingness to initiate opioid agonist therapy (OAT) with buprenorphine.

Healthy Controls

• Good general physical health.
• No current or past diagnosis of any psychiatric or substance use disorders.

Exclusion Criteria

All

• Any current major medical condition that, in the opinion of the Principal Investigator, poses a risk for PET procedures.
• Prior participation in research studies within the past year that would result in cumulative radiation exposure exceeding annual limits.
• Presence of ferromagnetic metal in the body, pacemaker, or other contraindications to MRI.
• Positive pregnancy test or current lactation.
• History of neurological conditions, including stroke or seizure disorders.
• Hematocrit values lower than 30

OUD Participants

• Current or past diagnosis of a serious psychiatric disorder.
• Current diagnosis of any substance use disorder other than nicotine or opioids.
• Use of any substances within the past 30 days.
• Current use of SSRIs or benzodiazepines or use within the past 30 days.
• Previous enrollment in the main study.

Healthy Controls

• Current or past diagnosis of any psychiatric disorder.
• Current diagnosis of any substance use disorder (excluding nicotine).
• Use of any substances within the past 30 days.