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Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Mayo Clinic · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT04344769

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–30 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
40
US sites recruiting
1
Study start
October 4, 2019
Record last updated
January 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to characterize oxidative stress and the Nrf2 antioxidant response in early stages of Autosomal Dominant Polycystic Kidney Disease (ADPKD), while identifying candidate biomarkers.

Conditions: Autosomal Dominant Polycystic Kidney Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria (ADPKD Subjects):

  • ADPKD (based on Ravine et al. criteria)
  • Class 1 B-E according to our imaging classification
  • Male and female subjects 18 - 30 years of age, inclusive
  • Estimated GFR> 60 mL/min/m2 (CKD-EPI equation)
  • Ability to provide written, informed consent.

Exclusion Criteria (ADPKD Subjects):

  • Class 2 according to our imaging classification
  • Concomitant systemic disease in the kidney (e.g. lupus, hepatitis B or C, amyloidosis)
  • Diabetes mellitus (fasting glucose > 126 mg/dL or treatment with insulin or oral hypoglycemics).
  • Predicted urine protein excretion in urinalysis >1 g/24 hrs
  • Abnormal urinalysis suggestive of concomitant glomerular disease.
  • Subjects having contraindications to, or interference with MRI assessments. [For example: ferromagnetic metal prostheses, aneurysm clips, severe claustrophobia, large abdominal/back tattoos, etc].
  • Female subjects that are pregnant

Inclusion Criteria (Healthy Subjects):

  • Male and female subjects 18 - 30 years of age, inclusive
  • Estimated GFR> 60 mL/min/m2 (CKD-EPI equation)
  • Ability to provide written, informed consent.

Exclusion Criteria (Healthy Subjects):

  • Previous personal or family history of kidney disease.
  • Concomitant systemic disease in the kidney (e.g. lupus, hepatitis B or C, amyloidosis)
  • Diabetes mellitus (fasting glucose > 126 mg/dL or treatment with insulin or oral hypoglycemics).
  • Presence of proteinuria
  • Abnormal urinalysis suggestive glomerular disease.
  • Subjects having contraindications to, or interference with MRI assessments. [For example: ferromagnetic metal prostheses, aneurysm clips, severe claustrophobia, large abdominal/back tattoos, etc]
  • Female subjects that are pregnant

Recruiting US locations

Study contacts (from the official record)

  • Ahmed Abdelfattah · Abdelfattah.Ahmed@mayo.edu
  • Maria V Irazabal, M.D., Ph.D · 507-884-5628 · irazabalmira.maria@mayo.edu
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Characterization of the Nrf2 Response in Patients With Autosomal… (NCT04344769) | Bored Studies