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Characterization of the Temporo-masseteric Nerve Block (TMNB) in Healthy Subjects

Rutgers, The State University of New Jersey · NCT05507164

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–64 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
20
US sites recruiting
1
Study start
October 10, 2022
Record last updated
December 5, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The proposed pilot study is aimed at preliminary characterization of the TMNB injection in 20 healthy volunteers. Assessment of bite-force distribution and surface electromyographic activity of the temporalis and the masseter muscles, at rest and clench, before and after unilateral TMNB injection, will be the primary outcome measures. Post-injection assessments will be performed at 30 minutes, 2 hours, and 2 weeks after the injection. Participants will be surveyed regarding their experience receiving the TMNB injection (secondary outcomes).

Being studied: Temporomasseteric Nerve Block

Conditions: Occlusion

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18-64 years of age
  • All ethnicity
  • Male and female sex
  • Fluent in written/spoken English
  • Never been diagnosed with TMD
  • No significant history of orofacial pain
  • \<5 headaches/month in the 3 months before enrollment
  • No reported use of a nightguard or occlusal splint 'No' to all questions on self-administered questionnaire for TMD screening:
  • Pain in jaw or temple on either side of the face in the last 30 days
  • Stiffness or pain in jaw upon awakening in the last 30 days
  • Any pain increase/reduction in the jaw/temple region during the last 30 days with
  • Chewing hard or tough food
  • Opening mouth or moving jaw forward or to the side
  • Hold teeth together/clenching/grinding/chewing gum
  • Using the jaw during activities such as talking, kissing or yawning

Exclusion Criteria

  • Traumatic injury/ surgery on face or jaw \< 6 months
  • current orthodontic treatment
  • pregnant or nursing,
  • kidney failure or renal dialysis,
  • heart disease or heart failure,
  • uncontrolled chronic respiratory disease/ hypertension/ diabetes
  • history of
  • seizures
  • hyperthyroidism
  • drug or alcohol abuse
  • psychiatric disorder/conditions requiring hospitalization
  • chemotherapy/radiation

Recruiting US locations

  • Rutgers School of Dental Medicine

    Newark, NJ 07103

    Site contact: Gayathri Subramanian · 973-972-3418 · subramga@sdm.rutgers.edu

Study contacts (from the official record)

  • Gayathri D Subramanian · 9739723418 · subramga@sdm.rutgers.edu
All healthy volunteers studies in New Jersey →
Characterization of the Temporo-masseteric Nerve Block (TMNB) in… (NCT05507164) | Bored Studies