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Childhood Trauma, Exercise, and Cognition

University of Texas at Austin · NCT05972265

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40–60 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
34
US sites recruiting
1
Study start
November 27, 2023
Record last updated
July 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study aims to identify and compare the effects of acute and chronic exercise interventions on cognition in middle-aged adults with cognitive complaints and a history of abuse or neglect in childhood. Each participant will be enrolled in the study for up to 78 days, in five parts following verification that the participant meets criteria to be included in the study: 1) initial assessment; 2) first acute exercise condition in lab, symptom measures, and neuropsychological testing; 3) second acute exercise condition in lab, symptom measures, and neuropsychological testing; and 4) 9-week exercise intervention or activity as usual outside of lab, with interview, symptom measures, and neuropsychological testing at three-week intervals.

Being studied: Moderate Intensity Exercise (one day); Placebo - Light Intensity Exercise (one day); Moderate Intensity Exercise (9 wks); Day 1 Assessments; Symptom Measures and Neuropsychological Tests; Day 36 Assessments; Day 57 Assessments; Day 78 Assessments

Conditions: Adverse Childhood Experiences

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • between 40 and 60 years of age
  • history of child abuse or neglect
  • have a complaint about memory, attention, or executive function
  • native or fluent English speaker
  • normal or corrected to normal vision and hearing
  • medically healthy

Exclusion Criteria

  • Score indicating a history of moderate-intensity activity, hard-intensity activity, or very-hard intensity activity on the Stanford Brief Activity Survey
  • current excessive alcohol or other substance use
  • eating disorder, bipolar disorder, schizophrenia spectrum disorders, or those judged to be an immediate suicide risk based on having an active plan with intent
  • autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), or other neurodevelopmental disorder
  • neurocognitive disorder, or illnesses or history of neurological events known to cause neurocognitive disorders (e.g., traumatic brain injury, status epilepticus, stroke)
  • reported chest pain or dizziness during exercise; any endorsed and not controlled medical condition that could make exercise contraindicated, including hypertension; heart disease; heart failure; hear rhythm disorders; heart valve disease; metabolic conditions; chronic obstructive pulmonary disease; pulmonary hypertension; cystic fibrosis; asthma; and bone, joint, or soft tissue problems
  • pregnancy, major medical disorders such as cancer, or any other condition believed to put a participant at risk

Recruiting US locations

  • University of Texas at Austin

    Austin, TX 78712

    Site contact: Erin Logue · 512-954-5510 · erin.logue@austin.utexas.edu

All healthy volunteers studies in Texas →
Childhood Trauma, Exercise, and Cognition (NCT05972265) | Bored Studies