Clinical and Scientific Assessment of Pain and Painful Disorders
National Center for Complementary and Integrative Health (NCCIH) · NCT02707029
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 12–120 · All sexes
- Healthy volunteers
- Accepted
- Study type
- Observational
- Target enrollment
- 10000
- US sites recruiting
- 1
- Study start
- July 22, 2016
- Record last updated
- October 13, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
Background
Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people to pleasant and unpleasant sensations. They will ask them questions about their pain. Researchers also want to see if these people are eligible for other research studies at the National Center for Complementary and Integrative Health.
Objectives
To study the experience of pain. Also to find people eligible to join other NIH studies.
Eligibility
People 12 years and older with and without pain disorders.
Design
Participants will be screened by phone.
Participants will have one required visit lasting about 2 hours. This may include:
- Medical history
- Physical exam
- Questionnaires about themselves and their pain experience
- Blood and urine tests
- MRI: They will lie on a table that slides into a cylinder. They will feel different sensations while completing tasks on a computer. This lasts 15 minutes to 2 hours.
- Quantitative sensory testing: They will be exposed to different pictures, sounds, tastes, and smells. They will also be exposed to pleasant and unpleasant sensations. These could include:
- Burning, itching, or cold sensations
- Pinpricks
- Pressure and pinches
- Electrocardiogram: Stickers on the chest record heart activity.
- Straps placed around the chest to measure breathing.
- Small sensors on the fingers or palms to measure pulse and sweating.
Participants may have up to 12 other outpatient study visits.
Participants may be recorded at the visits.
Conditions: Normal Physiology; Pain
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
- INCLUSION CRITERIA:
- Are >= 12 years of age
EXCLUSION CRITERIA
- Have difficulties with communication that make subjective pain assessment impossible or unreliable.
- Have acute medical or psychiatric health issues that create additional and substantial adverse risks related to study procedures. Medical examples are the acute complications of medical disease, such as asymptomatic hypertensive urgency, diabetic ketoacidosis, symptomatic hyperthyroidism, and unstable angina. Psychiatric examples are the acute complications of psychiatric disease, such as acute mania, paranoid delusions, or having acute panic attacks.
- Are participating in other ongoing research protocols such that phenotypic measurements would interfere with the conduct of an ongoing protocols or the receipt of a research treatment would influence the phenotypic measurements.
- Employees or staff that work at NCCIH.
- Pregnant women
Recruiting US locations
National Institutes of Health Clinical Center
Bethesda, MD 20892
Site contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) · 800-411-1222 · ccopr@nih.gov
Study contacts (from the official record)
- Keyonna L Berry · (301) 594-1782 · keyonna.berry@nih.gov
- Miroslav Backonja, M.D. · (301) 402-5679 · misha.backonja@nih.gov
Similar studies in Maryland
All healthy volunteers studies in Maryland →- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants
AstraZeneca
- Location
- Brooklyn, MD + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 21–60
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
Study of Intravenous ZMA001 in Healthy Subjects
National Heart, Lung, and Blood Institute (NHLBI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Cannabis Edibles
Johns Hopkins University
- Location
- Baltimore, MD
- Eligibility basics
- Ages 21–55