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Clinical Applications of Advanced Ophthalmic Imaging

University of Miami · NCT03135327

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–99 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
5000
US sites recruiting
1
Study start
January 1, 2007
Record last updated
September 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls.

There are two phases in this study. The first phase is an observational phase which studies the eye in various conditions. The second phase is an interventional phase which studies the changes in the eyes after taking an over-the-counter medical food (Ocufolin) for 6 months.

Being studied: Ocufolin

Conditions: Multiple Sclerosis; Dry Eye Syndromes; Diabetic Retinopathy; Presbyopia; Myopia; Dementia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Observational Phase 1 Group

Inclusion Criteria

  • Self-reported normal healthy subjects;
  • Clinical diagnosis of Alzheimer's Disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetics and stroke;
  • Who can keep the eye open for imaging.

Exclusion Criteria

  • who can not read and sign the ICF;
  • who can not receiving ophthalmic imaging;
  • who cannot tolerate bright light during imaging.

Interventional Phase 2 Group:

Inclusion criteria

The participant will be eligible for entry in the study if s/he:

  • Is at least 18 years old and has full legal capacity to volunteer;
  • Has read and signed the IRB Informed Consent Document;
  • Is willing and able to follow participant instructions;
  • Has clear corneas and crystalline lens;
  • Initial visual acuities were 20/80 or better;
  • MTHFR C677TT homozygous, or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurismal vascular retinopathy disease;
  • Hemoglobin A1c is 10 or less;
  • Normotensive with or without medications;
  • Without retinal capillary dropout or macular edema;
  • Blood homocysteine > 9.

Exclusion criteria

The subjects will be ineligible for entry into the study if s/he:

  • Has an active ocular disease;
  • Has had surgery or an eye injury within 6 months.

Recruiting US locations

  • Bascom Palmer Eye Institute

    Miami, FL 33136

    Site contact: Jianhua Wang, MD, PHD · 305-482-5010 · jwang3@med.miami.edu

Study contacts (from the official record)

  • Jianhua Wang, MD, PhD · 3054825010 · jwang3@med.miami.edu
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Clinical Applications of Advanced Ophthalmic Imaging (NCT03135327) | Bored Studies