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Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

University of Colorado, Denver · with National Institutes of Health (NIH), National Institute on Drug Abuse (NIDA) · NCT06526286

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 12–89 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
200000
US sites recruiting
1
Study start
July 7, 2026
Record last updated
September 21, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The objective of this study is to evaluate the impact of clinical decision support (CDS) in the form of an alert to identify patients who may be at risk of opioid use disorder (OUD) and a clinical care pathway helping providers treating patients with opioid use disorder. The pathway provides health care providers with information and suggestions for screening and treatment of opioid use disorder, including treatment with medications. The 2022 Centers for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends providers asses for and treat opioid use disorder using approved medications for opioid use disorder (MOUD). This project will implement a passive CDS alert when a provider prescribes an opioid to a patient who may be at risk of opioid use disorder. Providers will also have link access to a clinical care pathway providing support for OUD screening and treatment. Before and after comparisons of buprenorphine (a medication used to treat opioid use disorder) prescribing by providers and outcomes of patients will be examined based on medical records data collected during routine care. The study period will be approximately 18 months.

Being studied: Medications for Opioid Use Disorder Pathway Clinical Decision Support (CDS)

Conditions: Medication Abuse; Harm Reduction; Opioid Use Disorder; Supportive Care

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Primary care encounter AND
  • Current opioid prescription (not buprenorphine) and Active opioid medications over the last 90 days OR
  • Documented as on local Pain Registry "Does the patient fit the criteria to be included on the Pain Registry?" OR
  • Has active problem list diagnosis of long-term (current) use of opiate analgesic OR
  • Is taking >=90 morphine milligram equivalents (MME) per day OR
  • Prior positive toxicology screen for illicit drugs OR
  • Diagnosis of opioid use disorder

Exclusion Criteria

  • Active cancer diagnosis in the last 1 year
  • Hospice care/palliative care order
  • Sickle cell disease diagnosis

Recruiting US locations

  • UCHealth

    Aurora, CO 80045

    Site contact: Heather Tolle · 720-848-6777 · heather.tolle@cuanschutz.edu

Study contacts (from the official record)

  • Heather Tolle, PhD · 303-724-9924 · heather.tolle@cuanschutz.edu
All healthy volunteers studies in Colorado →
Clinical Decision Support to Increase Use of Medications for… (NCT06526286) | Bored Studies