Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital

Inclusion Criteria

• Has cognitive ability to provide informed consent
• Aged 22 years or older
• Hospitalized with hypoxemia/respiratory distress
• Diagnosis of COPD
• Candidate for/currently prescribed nasal high flow (flow rate of at least 25 L/min) with supplemental oxygen, as assessed by the investigator
• Expected duration of oxygen and nasal high flow therapy >24 hours (not necessarily continuous)

Exclusion Criteria

• Receiving Non Invasive Ventilation (NIV) or indicated for NIV as per European Respiratory Society /American Thoracic Society guidelines
• Hemodynamic instability (systolic blood pressure \<90mmHg or requirement for vasopressor or inotropic support)
• Patient receiving end of life care
• Nasal or facial conditions precluding use of nasal high flow
• Pregnancy or breastfeeding
• Cognitive impairment or impaired consciousness precluding informed consent
• Unsuitable for adhesive finger pulse oximetry, as assessed by the investigator
• Any other condition which, at the investigator's discretion, is believed to present a safety risk to the patient if included
• The presence of any active comorbidities that affect the patient's condition importantly in the next 30 days, as assessed by the investigator
• Has already participated in this clinical trial