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Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training

The Cleveland Clinic · NCT07681973

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
52
US sites recruiting
1
Study start
December 9, 2025
Record last updated
July 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated.

The primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.

Being studied: Smell Training

Conditions: Smell Loss; Chronic Rhinosinusitis (CRS)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age less than 18 years-old
  • Present to rhinology clinic with CRS with nasal polyps
  • Sense of smell loss for any reason (other than trauma or tumor)

Exclusion Criteria

  • Patients \< 18 years of age
  • Individuals with unilateral nasal polyps
  • Autoimmune diseases
  • Ciliary disorders
  • Cystic fibrosis
  • Smell loss due to tumors or trauma

Recruiting US locations

  • The Cleveland Clinic

    Cleveland, OH 44195

    Site contact: John O'Neill · 4405062611 · ONEILLJ2@ccf.org

Study contacts (from the official record)

  • John O'Neill · 4405062611 · ONEILLJ2@ccf.org
  • Christopher Novicky · 216-444-7018 · novickc@ccf.org
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Cognitive and Immunologic Profiles of Patients With Olfactory… (NCT07681973) | Bored Studies