RecruitingPhase 2/Phase 3
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
Price Vision Group · NCT07841470
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Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 10–90 · All sexes
- Healthy volunteers
- Not accepted (a condition is required)
- Study type
- Interventional · Phase 2, Phase 3
- Target enrollment
- 500
- US sites recruiting
- 1
- Study start
- October 1, 2025
- Record last updated
- September 25, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
Being studied: Riboflavin 0.1% ophthalmic solution and pulsed light; Riboflavin 0.1% ophthalmic solution and non-pulsed light
Conditions: Keratoconus; Corneal Ectasia
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Diagnosis of keratoconus or corneal ectasia
- Provision of written informed consent
Exclusion Criteria
- Previous ocular condition in the study eye that may predispose for future complications including history of corneal disease (e.g., herpes simplex, herpes zoster keratitis, recurrent erosion syndrome, corneal melt, corneal dystrophy, etc.)
- Clinically significant corneal scarring in the proposed treatment zone
- History of chemical injury or delayed epithelial healing in the study eye
- Known sensitivity to study medication
- A current condition, including clinically significant dry eyes or use of medications know to induce dry eye symptoms, that, in the treating physician's opinion, would interfere with or prolong epithelial healing
- Pregnancy (including plan to become pregnant) or lactation during the course of the study
Recruiting US locations
Price Vision Group
Indianapolis, IN 46260
Site contact: Marianne Price, PhD · 317-814-2990 · mprice@cornea.org
Study contacts (from the official record)
- Marianne Price, PhD · 317-814-2990 · mprice@cornea.org
- Francis Price, MD · 317-814-2823 · fprice@pricevisiongroup.net