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Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

Dermed Diagnostics, Inc. · with Northwestern University · NCT07230964

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Not applicable
Target enrollment
6
US sites recruiting
1
Study start
April 30, 2026
Record last updated
May 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate the effectiveness of impedance cardiography (ICG), the HYPERGRAPH test, in detecting left ventricular decompensation in patients with aortic stenosis, compared to cardiac magnetic resonance (CMR) imaging findings. The study aims to obtain usable ICG test data on six patients with aortic stenosis who have recently undergone CMR scans with late gadolinium enhancement, and who do not have a history of myocardial infarction or cardiac amyloidosis. The hypothesis to be tested is that the HYPERGRAPH can accurately detect left ventricular decompensation associated with replacement fibrosis obtained from CMR imaging.

Being studied: Impedance Cardiography Upright/Supine Test

Conditions: Aortic Stenosis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • • Male or female at least 18 years of age.
  • No prior history of myocardial infarction or cardiac amyloidosis.
  • Recent CMR scan with late gadolinium enhancement or scheduled for CMR scan with late gadolinium enhancement.
  • A history of:
  • Moderate aortic stenosis and no replacement fibrosis OR Moderate aortic stenosis and symptoms who has replacement fibrosis OR Severe aortic stenosis with replacement fibrosis prior to aortic valve replacement.
  • Able to comprehend and provide informed consent in English.
  • Participants must have intact, healthy skin at the electrode application sites.

Exclusion Criteria

  • • Under 18 years of age
  • Pregnant or breastfeeding women
  • Unable to consent
  • Prisoners
  • History of myocardial infarction
  • History of cardiac amyloidosis
  • Patients with any metal or implant such as IUD, braces, metal fragments implants in the eye, pacemakers (especially Minute Ventilation pacemakers with the MV function activated) defibrillators, or any other electronic cardiac implant.
  • Claustrophobic or afraid or small places.
  • Severe obesity (BMI > 40) that impairs accurate ICG measurement due to difficulties in electrode placement or excessive impedance.
  • Active skin conditions, such as rashes, open wound or significant skin sensitivity at the electrode placement sites.

Recruiting US locations

  • Northwestern University

    Chicago, IL 60611

    Site contact: Michael Markl, PhD · 312-926-5268 · mmarkl@northwestern.edu

Study contacts (from the official record)

  • Arthur P DeMarzo, MSc · 1-630-668-4644 · ademarzo.dermed@att.net
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Correlation Between an Impedance Cardiography Test for… (NCT07230964) | Bored Studies