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Countermeasures to Circadian Misalignment

Colorado State University · with University of Colorado, Denver, Salk Institute for Biological Studies · NCT04966351

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–35 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
32
US sites recruiting
1
Study start
July 7, 2021
Record last updated
July 24, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.

This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.

Being studied: Time-restricted feeding; Circadian Misalignment

Conditions: Circadian Rhythm Sleep Disorder of Shift Work Type; Metabolic Disease; Insulin Sensitivity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18-35 old; men and women; equal numbers of women and men will be included.
  • Body Mass Index (BMI) between 20.0 and 24.9 ("normal" weight).
  • Physical activity history: inactive to habitual moderate physical activity level
  • Sleep/wake history: habitual sleep duration between 7-9.25 hours.
  • Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay.

Exclusion Criteria

  • Any clinically significant medical, psychiatric, or sleep disorder
  • Use of prescribed medications/supplements/illicit drugs within one month prior to study
  • History of shift work in year prior to study, or travel more than one time zone in three weeks prior to study. [NOTE: Subjects can be studied at a later date.]
  • Women with history of prior gynecological pathology, \<1 year post-partum, breast-feeding and/or pregnant.
  • Non-English speakers will be excluded, as we do not have access to a translator who could rely accurate information to the participant for the consent or throughout the study.

Recruiting US locations

  • Colorado State University

    Fort Collins, CO 80523

    Site contact: Ellen Lyon, M.S. · 970-491-3103 · sleep-study@colostate.edu

Study contacts (from the official record)

  • Josiane L Broussard, PhD · 9704913103 · josiane.broussard@colostate.edu
  • Ellen Lyon, MS · 9704913103 · ellen.lyon@colostate.edu
All diabetes studies in Colorado →
Countermeasures to Circadian Misalignment (NCT04966351) | Bored Studies