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Craving & Decision-Making

Rutgers, The State University of New Jersey · with National Institute on Drug Abuse (NIDA) · NCT06440577

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
160
US sites recruiting
1
Study start
June 18, 2024
Record last updated
June 4, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Craving is the strong desire for something, such as for substances in drug addiction and food or other activities in everyday life. Recent work suggests craving can influence how people make decisions and assign value to choice options available to them, yet the neural mechanisms underlying these interactions between craving and valuation remain unknown. To address this, this study uses cognitive decision-making tasks that measure how much individuals will pay (from a study endowment) to have everyday consumer items or snack foods when they crave something specific (opioids or a specific snack, respectively). First, the study will identify the neural mechanisms for how drug craving (craving for opioids) interacts with valuation for consumer items that have associations with drug use or not in people receiving treatment for opioid use disorder (OUD). This will be evaluated in the activity patterns and interactions among brain regions involved in craving and value assignment during decision-making. Then, the study will examine for parallel mechanisms for how food craving (craving for a specific snack) interacts with valuation for snack food items that have similar features to the craved snack or not in people receiving treatment for OUD and non-psychiatric community control participants.

Being studied: Audio-visual stimuli (Neutral-Relaxing); Audio-visual stimuli (Drug); Audio-visual stimuli (Non-Food); Audio-visual stimuli (Food)

Conditions: Decision Making

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • At least 18 years of age
  • Willingness to follow study requirements, as evidenced by an ability to provide written informed consent and read, understand, and complete the study procedures
  • Minimum of 6th grade reading level

Additional inclusion criteria for participants with OUD:

  • Primary diagnosis of OUD encompassing heroin and/or painkiller use
  • Receiving medications for OUD treatment on an outpatient basis
  • At least 12-month history of opioid use

Exclusion Criteria

  • Unable to speak or read English
  • Active psychosis or mania
  • Current or past schizophrenia diagnosis
  • History of intellectual disability or developmental or neurological disorder, seizures or epilepsy, or loss consciousness lasting more than 30 minutes
  • Severe medical conditions requiring hospitalization or that, in the opinion of the study staff could compromise study participation
  • MRI contraindications (claustrophobia, nonremovable piercings, certain metal in the body etc.) or pregnancy

Additional exclusion criteria for community control participants:

  • Positive urine drug screen
  • Current or past problematic substance use other than nicotine, and alcohol abuse confined to college or military service
  • Current or past bipolar disorder diagnosis
  • Use of central nervous system medications within the past 6 weeks (e.g., antidepressants, Ritalin)

Recruiting US locations

  • Rutgers, The State University of New Jersey

    Piscataway, NJ 08854

    Site contact: Anna Konova, PhD

Study contacts (from the official record)

  • Anna Konova, PhD · 732-235-4335 · anna.konova@rutgers.edu
All nutrition & metabolism studies in New Jersey →
Craving & Decision-Making (NCT06440577) | Bored Studies