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Cytokine Response to Abdominal Wall Reconstruction

Northwestern University · NCT07422584

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
25
US sites recruiting
1
Study start
February 3, 2026
Record last updated
February 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure. The project integrates perioperative cytokine profiling, direct measurement of intra-abdominal pressure, and detailed clinical outcomes to define the biologic and physiologic consequences of high-tension closure.

The study includes three cohorts: 1) Healthy controls (N=5), 2) High-tension fascial closure AWR patients (N=10), 3) Low-tension fascial closure AWR patients (N=10). Fascial closure tension will not be altered for the purpose of the study and will be determined by the operating surgeon as part of routine clinical decision-making.

Being studied: Not applicable- observational study

Conditions: Incisional Ventral Hernia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Surgical Participants

  • Adults aged 18 years or older
  • Scheduled to undergo open retromuscular ventral hernia repair
  • Able to provide written informed consent Healthy Control Participants
  • Adults aged 18 years or older
  • No known inflammatory, autoimmune, or immunologic disease
  • Able to provide written informed consent

Exclusion Criteria

  • Emergent or urgent cases
  • Pregnancy
  • Chronic systemic steroid use or immunosuppressive therapy
  • Active infection at the time of enrollment
  • Known autoimmune or inflammatory disease
  • End-stage organ failure
  • Abdominal surgery within the preceding 60 days

Recruiting US locations

  • Northwestern Memorial Hospital

    Chicago, IL 60611

    Site contact: Megan Melland-Smith, MD · 312-907-1414 · megan.mellandsmith@nm.org

Study contacts (from the official record)

  • Megan Melland-Smith, MD · 312-907-1414 · megan.mellandsmith@nm.org
  • Nancy Ly, MD · 262-455-1560 · nancy.ly@nm.org
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Cytokine Response to Abdominal Wall Reconstruction (NCT07422584) | Bored Studies