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Dehydration, Rehydration, and Impact on Physiology

Texas Tech University · NCT07084675

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 45–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
15
US sites recruiting
1
Study start
July 15, 2025
Record last updated
September 17, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65.

Aim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFkB), mitochondrial fragmentation, and autophagy in circulating PBMCs.

Aim 2: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on fasting glucose, sleep performance, and strength performance.

Participant will

complete a 4-day hydration protocol, followed by a 4-day dehydration protocol, and then a 4-day rehydration protocol.

attend five laboratory visits for testing: Day 1: Informed consent and familiarization Day 2: Pre-hydration testing (before the 4-day hydration protocol) Day 3: Pre-dehydration testing (before the dehyration protocol) Day 4: Post-dehydration testing (after the dehydration protocol) Day 5: Post-rehydration testing (after the rehydration protocol)

Being studied: Hydration-Dehydration-Rehydration Protocol (HDR)

Conditions: Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Apparently Healthy
  • BMI \< 30 kg/m2
  • Body weight is at least 110 lbs

Exclusion Criteria

  • Currently pregnant
  • Have Type 1 Diabetes or Type 2 Diabetes
  • Have chronic kidney disease or a history of kidney stones
  • Have hypertension
  • Take medications that can cause fluid retention, such as corticosteroids, chronic use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Hormonal Therapies (e.g., estrogen, androgens or anabolic steroids), Antihypertensives, Psychiatric Medications (e.g., Lithium), Vasodilators
  • Take medications that reduce fluid retention: diuretics, and RAAS Inhibitors (e.g., ACE inhibitors and ARBs)

Recruiting US locations

  • Texas Tech University

    Lubbock, TX 79409

    Site contact: Hui Ying Luk, Ph.D. · 806-834-0827 · huiying.luk@ttu.edu

Study contacts (from the official record)

  • Hui Ying Luk, Ph.D. · 806-834-0827 · huiying.luk@ttu.edu
All healthy volunteers studies in Texas →
Dehydration, Rehydration, and Impact on Physiology (NCT07084675) | Bored Studies