Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention

Inclusion Criteria

• Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and/or parent/legal guardian report and confirmed by a structured interview
• screening positive for two or more risk factors targeted by the intervention
• Participants and parent(s)/legal guardian(s) agree to participate
• psychiatrically stable and have no major changes in antidepressant, stimulant, or antipsychotic medication in the past 4 weeks.

Exclusion Criteria

• Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview
• Current or past antipsychotic medication use to specifically treat a psychotic disorder
• major medical and neurological conditions
• moderate to severe intellectual disabilities or mild intellectual disabilities but expected to have difficulty completing the study assessments;
• current drug or alcohol use that impacts functioning and study engagement;
• Not able to give assent, permission, or consent.
• Not able to undergo MRI.