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Development of a Noninvasive Metric to Measure Small Bowel Sensation - The Small Intestine Stress Test

Mayo Clinic · NCT07817706

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
20
US sites recruiting
1
Study start
September 1, 2026
Record last updated
October 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this research is to identify the concentration of mannitol solution (a type of sugar alcohol) that will generate a range of symptoms in individuals without Disorders of Gut Brain Interaction (DGBI) to establish the normative range of responses to small bowel (SB) distension.

Being studied: Mannitol Solution 76 mOsm/L; Mannitol Solution 189 mOsm/L; Mannitol Solution 325 mOsm/L; Scintigraphy

Conditions: Disorders of Gut Brain Interaction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • No current gastrointestinal symptoms
  • No prior history of GI disorders, in particular DGBIs
  • Ability to provide informed consent
  • Ability to participate in study procedures
  • Absence of other diseases (structural or metabolic) which could interfere with interpretation of the study results
  • For females, must not be pregnant or lactating due to radiation exposure.
  • Stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardioprotection, and birth control are permissible.

Exclusion Criteria

  • Subjects on any medications that impact transit or integrity of small bowel mucosal barrier (e.g. chronic NSAIDS) of the GI tract will be excluded.
  • Patients with prior bowel surgery (not including appendectomy and cholecystectomy)
  • Patients who may have altered sensation (central sensitization or conditions that may induce bowel hyperalgesia) based on PI review of medical history (ie, fibromyalgia, endometriosis, chronic pelvic pain)

Recruiting US locations

  • Mayo Clinic

    Rochester, MN 55905

    Site contact: Taylor Hines · 507-538-9959

Study contacts (from the official record)

  • Taylor Hines · 507-538-9959 · hines.taylor@mayo.edu
All healthy volunteers studies in Minnesota →
Development of a Noninvasive Metric to Measure Small Bowel… (NCT07817706) | Bored Studies