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Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer

Memorial Sloan Kettering Cancer Center · with New York Genome Center · NCT03922893

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Any age listed · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
1500
US sites recruiting
7
Study start
April 17, 2019
Record last updated
December 15, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.

Being studied: Family History Information; ORAGENE; Blood; Skin Biopsy

Conditions: Cancer

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Individuals who have undergone clinical and/or research genetic evaluation, found to have or not have a germline genetic variant (pathogenic, likely pathogenic, variant of uncertain/unknown significance, likely benign).
  • Individuals with or without a personal history of malignant or pre-malignant lesions who demonstrate: a) clinical findings suggestive of a genetic cancer susceptibility syndrome including very early age at onset, multiple primary malignancies, or other features; and/or b) family histories suggestive of a genetic cancer susceptibility syndrome, or c) other features suggesting inherited etiology of malignancy as determined by the PI.
  • Family members of the above participants. Both children (with parental consent as age appropriate) and adults are eligible to participation.
  • Individuals may or may not be enrolled MSK patients; probands may be referred to (or self-referred to) the study and may be enrolled at discretion of the PI and if able to provide informed consent.
  • Biospecimens derived from deceased family members may be used for research in this study if consent if provided by the executor of the estate of that individual.

Exclusion Criteria

  • Patients will be excluded from this study if he/she has physical, cognitive or psychiatric conditions that interfere with ability to give meaningful informed consent.

Recruiting US locations

  • Memorial Sloan Kettering Basking Ridge (Consent only)

    Basking Ridge, NJ 07920

    Site contact: Kenneth Offit, MD, MPH · 646-888-4059

  • Memorial Sloan Kettering Monmouth (Consent only)

    Middletown, NJ 07748

    Site contact: Kenneth Offit, MD, MPH · 646-888-4059

  • Memorial Sloan Kettering Bergen (Consent only )

    Montvale, NJ 07645

    Site contact: Kenneth Offit, MD, MPH · 646-888-4059

  • Memorial Sloan Kettering Cancer Center @ Commack (Consent Only)

    Commack, NY 11725

    Site contact: Kenneth Offit, MD, MPH · 646-888-4059

  • Memorial Sloan Kettering Westchester (Consent only)

    Harrison, NY 10604

    Site contact: Kenneth Offit, MD, MPH · 646-888-4059

  • Memorial Sloan Kettering Cancer Center

    New York, NY 10065

    Site contact: Kenneth Offit, MD, MPH · 646-888-4059

  • Memorial Sloan Kettering Nassau (Consent only)

    Uniondale, NY 11553

    Site contact: Kenneth Offit, MD, MPH · 646-888-4059

Study contacts (from the official record)

  • Kenneth Offit, MD, MPH · 646-888-4059 · offitk@mskcc.org
  • Mark Robson, MD · 646-888-5486 · robsonm@mskcc.org
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Discovering New Genetic Markers in Adults and Children Who May Be… (NCT03922893) | Bored Studies