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DNA Methylation and Vascular Function

University of Illinois at Chicago · with National Heart, Lung, and Blood Institute (NHLBI) · NCT03527420

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
80
US sites recruiting
1
Study start
October 11, 2019
Record last updated
September 15, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Being studied: Exercise training

Conditions: Obesity; Vascular Dysfunction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • BMI ≥ 35 kg/m2
  • Between ages 18-50 years
  • Not pregnant
  • Approved for a bariatric surgery

Exclusion Criteria

  • To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
  • Pregnant women will be excluded, as they will not be eligible for bariatric surgery
  • Current smokers
  • Currently abusing alcohol or drugs

Recruiting US locations

  • University of Illinois at Chicago

    Chicago, IL 60612

    Site contact: Abeer M Mohamed, MD, PhD · 312-355-8099 · amahmo4@uic.edu

Study contacts (from the official record)

  • Abeer Mohamed, MD, PhD · 3127539998 · amahmo4@uic.edu
All weight loss studies in Illinois →
DNA Methylation and Vascular Function (NCT03527420) | Bored Studies