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Double Simultaneous Uterotonic Agents Versus Single Agent Regimen to Prevent Early Postpartum Hemorrhage

Stony Brook University · NCT05245227

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 3
Target enrollment
1358
US sites recruiting
1
Study start
January 27, 2025
Record last updated
May 4, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

To determine the effectiveness of using two medications simultaneously versus one medication, as is standard of care, in preventing early postpartum hemorrhage.

There have been studies that looked at giving two medications and that there were reduced odds of postpartum hemorrhage.

Specific Aim 1: Determine if double simultaneous uterotonic agent regimen (misoprostol and oxytocin) is superior to single agent (oxytocin only) in reducing postpartum hemorrhage.

Specific Aim 2: Determine any potential side effects of a double simultaneous uterotonic agentregimen (misoprostol and oxytocin) versus a single agent (oxytocin only).

Being studied: Sublingual Misoprostol; IV Oxytocin

Conditions: Postpartum Hemorrhage

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • All women 18 years and older admitted to delivery at Stony Brook University hospital who agree to participate in the study

Exclusion Criteria

  • Women under 18 years old
  • Women with known coagulation disorders
  • Women with planned cesarean hysterectomy
  • Women with known placental accreta spectrum disorders
  • Women with known allergy to prostaglandins

Recruiting US locations

  • Stony Brook University

    Stony Brook, NY 11794

    Site contact: Erin Cassella · 631-444-7650 · erin.casella@stonybrookmedicine.edu

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Double Simultaneous Uterotonic Agents Versus Single Agent Regimen… (NCT05245227) | Bored Studies