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RecruitingAccepts healthy volunteersEarly Phase 1

Effect of C-peptide on Hypoglycemic Counterregulation

University of Cincinnati · NCT06470295

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–40 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
38
US sites recruiting
1
Study start
June 1, 2024
Record last updated
February 17, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose production and increases the depth and duration of hypoglycemic episodes. We have observed that the naturally occurring protein C-peptide increases glucagon secretion in dogs during insulin-induced hypoglycemia, which increases hepatic glucose production; the experiments in this application will shed light on the translation of this finding to the human.

Being studied: Saline; C-peptide

Conditions: Hypoglycemia; Type 1 Diabetes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • BMI less than 30 kg/m2

Exclusion Criteria

  • pregnant or lactating women cigarette smoking presence of HIV or hepatitis presence of cardiovascular disease presence of microvascular disease

Recruiting US locations

  • University of Cincinnati

    Cincinnati, OH 45267-0547

    Site contact: Jason Winnick, PhD · 513-558-4437 · jason.winnick@uc.edu

Study contacts (from the official record)

  • Jason Winnick, PhD · 513-558-4437 · jason.winnick@uc.edu
  • Natalie Whitsett · 513-558-4489 · whitsenh@ucmail.uc.edu
All diabetes studies in Ohio →
Effect of C-peptide on Hypoglycemic Counterregulation (NCT06470295) | Bored Studies