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RecruitingAccepts healthy volunteersPhase 4

Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane

Baylor College of Medicine · NCT03384563

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 1 mo–3 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
180
US sites recruiting
1
Study start
February 18, 2018
Record last updated
September 22, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.

Being studied: Dexmedetomidine

Conditions: Pediatric Anesthesia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Exclusion Criteria

  • Interstitial lung disease, chest wall disease, or bronchospastic disease with no flare-ups in the past 2 weeks of presentation
  • History of difficult intubation or ventilation
  • Airway malformation
  • Congenital heart disease
  • Cardiac arrhythmias
  • Central nervous system disease, including developmental delay, cerebral palsy, or seizure disorder
  • History of or family history of malignant hyperthermia
  • Electrolyte disorders
  • Gastrointestinal disease
  • Hepatic dysfunction
  • Renal dysfunction
  • Metabolic disease, such as diabetes
  • Obesity, defined as a body mass index greater than the 95% percentile for age
  • Preterm infant (less than 37 weeks gestational age) 15. Use of any medications (anticonvulsants, opioids, benzodiazepines, antibiotics, antihistamines drugs that induce hepatic enzymes) that may affect MAC.

Inclusion Criteria

All patients age 1 month- 3 years presenting for surgery.

Recruiting US locations

  • Texas Children's Hospital

    Houston, TX 77030

    Site contact: Rahul Baijal · 832-824-5800 · rbaijal@bcm.edu

Study contacts (from the official record)

  • Margaret Owens-Stuberfield · 832-824-5800 · owensstu@bcm.edu
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Effect of Dexmedetomidine on the Minimum Alveolar Concentration of… (NCT03384563) | Bored Studies