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Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes

Mayo Clinic · NCT06424106

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 25–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
60
US sites recruiting
1
Study start
April 1, 2025
Record last updated
April 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.

Being studied: Glucagon; Glucose

Conditions: PreDiabetes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Individuals with normal or impaired fasting glucose and normal or impaired glucose tolerance

Exclusion Criteria

  • HbA1c less than 6.5%
  • Use of any glucose-lowering agents including metformin or sulfonylureas.
  • For female subjects: positive pregnancy test at the time of enrollment or study
  • History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
  • Active systemic illness or malignancy.
  • Symptomatic macrovascular or microvascular disease.

Recruiting US locations

Study contacts (from the official record)

  • Kim Osmundson, CCRP · 507-255-0907 · Osmundson.Kimberly@mayo.edu
  • Jeanette Laugen · 507-255-8110 · Laugen.Jeanette@mayo.edu
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Effect of Glucagon on Fasting Insulin Secretion and Glucose… (NCT06424106) | Bored Studies