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RecruitingAccepts healthy volunteersPhase 2

Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes

George Washington University · with University of North Carolina, Diabetes Sisters · NCT06948825

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
60
US sites recruiting
1
Study start
October 27, 2025
Record last updated
January 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to evaluate the effectiveness of a 6-month lifestyle intervention compared to Metformin in postpartum women who have delivered a singleton, live born infant within the last 12 weeks to 1 year and had a pregnancy complicated by gestational diabetes. The main question this study aims to answer is:

Is a Lifestyle Intervention or Metformin more effective for weight loss in postpartum women with recent gestational diabetes?

Researchers will compare a 6-month Lifestyle Intervention and Metformin to see if either intervention is more effective in achieving weight loss and improving health outcomes.

Participants will

  • Attend an in-person baseline visit to receive a Bluetooth-enabled scale and Fitbit, have blood drawn for testing, and have their height, weight, and blood pressure measured. Participants will also be asked to bring in their infant, and the study team will measure the infant's weight and length.
  • Track diet, physical activity, and weight using the Fitbit and Looseit! apps.
  • Attend weekly online group sessions for the first 4 weeks, then biweekly sessions.
  • If not meeting weight loss goals, be randomized to either Enhanced Lifestyle Intervention or Metformin arms of the study.
  • If randomized to Metformin, participants will attend one in-person meeting with the study provider, get blood drawn for testing, and undergo a urine pregnancy test before starting the medication.
  • Continue with biweekly group sessions or have regular check-in calls.
  • If randomized to the Enhanced Lifestyle Intervention, participants will get a free Instacart membership, a 1:1 session with the study health counselor focused on meal planning and free grocery delivery once a week for the remainder of the study.
  • Participants will meet every other week via Zoom with the health counselor and other participants in the enhanced lifestyle arm.
  • At the end of the 6 months, all participants will come for an in-person visit to get blood drawn for testing. Participants will also be asked to bring in their infant, and the study team will measure the infant's weight and length.

Being studied: Metformin Hcl 850Mg Tab; Lifestyle Intervention; Enhanced Lifestyle Intervention

Conditions: Weight Loss; Gestational Diabetes Mellitus in Pregnancy; Postpartum Care

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Mothers between 8 weeks and 12 months postpartum from a pregnancy complicated by GDM will be recruited. The research team will begin recruiting women who are at least 8 weeks postpartum to provide time to describe the study and answer any questions. Mothers who want to participate will be enrolled in the study between 12 weeks and 12 months postpartum.
  • BMI of 25 kg/m2 to 45 kg/m2
  • Singleton delivery
  • Participants must also have a working cell phone, be willing to accept email or text messages attend Zoom calls, and be willing to be potentially randomized to drug therapy with Metformin.

Exclusion Criteria

  • Pregnant or planned pregnancy within the next 6 months.
  • Participation in any other weight loss program or taking weight loss medication.
  • Normal or underweight BMI (BMI \< 24.9 kg/m2)
  • Multi-fetal (twins or triplets) gestation
  • Women with type 1 or type 2 diabetes, malignancy, other serious co-morbidities (advanced kidney disease, NYHA class 3-4 CHF, advanced COPD), schizophrenia or other major psychiatric disease, and substance abuse or AIDS.
  • Women whose infants have significant medical conditions, such as congenital heart disease, renal impairment, or hepatic impairment.

Recruiting US locations

  • Milken Institute School of Public Health - The George Washington University

    Washington D.C., DC 20052

    Site contact: Jennifer Gomez, MPH · 202-994-2582 · Jengomez291@gwu.edu

Study contacts (from the official record)

  • Jennifer R Gomez Berrospi, MPH · 202-994-2582 · Jengomez291@gwu.edu
  • Wanda Nicholson, MD · wanda.nicholson@email.gwu.edu
All weight loss studies in District of Columbia →
Effectiveness Study of a Lifestyle Intervention Versus Metformin… (NCT06948825) | Bored Studies