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Effects of High Altitude on AMPK Activation

University of Colorado, Denver · NCT02391519

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Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
84
US sites recruiting
1
Study start
January 2016
Record last updated
February 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.

Being studied: Collection of myometrial, cord blood, and placental tissue samples

Conditions: Pregnancy; IUGR; Preeclampsia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Women scheduled for cesarean delivery at University of Colorado Hospital (Denver, 1600 m) and St. Anthony's Summit Medical Center (Summit County, 3000 m)
  • Cesarean delivery at a prescheduled time without any labor, typically at 39 weeks gestation

Exclusion Criteria

  • Women will be excluded if there are co-existing medical diagnoses that are known to affect vascular parameters (i.e., diabetes mellitus, gestational diabetes, any hypertensive disorder of pregnancy, or a current smoker).
  • Women with multiple gestations and preterm deliveries will also be excluded.

Recruiting US locations

  • University of Colorado Denver Anschutz Medical Campus

    Aurora, CO 80045

    Site contact: Lorna Moore, PhD

Study contacts (from the official record)

  • Lorna Moore, PhD · 303-724-7474 · lorna.moore@ucdenver.edu
All pregnancy studies in Colorado →
Effects of High Altitude on AMPK Activation (NCT02391519) | Bored Studies