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Endothelial Dysfunction After SCI

Craig Hospital · with University of Colorado, Boulder, Denver Health and Hospital Authority · NCT07227727

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
40
US sites recruiting
1
Study start
July 31, 2025
Record last updated
November 14, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.

Being studied: Intra-arterial Infusion of Vasoactive Agents; Intra-arterial Vitamin C Infusion; Blood Sampling

Conditions: Spinal Cord Injuries; Endothelial Dysfunction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

SCI Inclusion Criteria

  • Over age 18 years
  • Chronic (>12 months) SCI
  • Motor complete (AIS A/B) SCI
  • Paraplegia (neurological level of injury [NLI] at T2 or below)

Non-injured Inclusion Criteria

  • Over age 18 years

Exclusion Criteria (Both SCI and Non-injured)

  • Overt chronic diseases as assessed by: a) clinically documented medical history; b) physical examination; c) blood pressure and ECG at rest; and d) complete blood chemistries and hematological evaluation.
  • Active infection
  • Recent (\< 3 months) surgery
  • Current smoking history (within past 12 months)
  • Report more than low-risk alcohol consumption
  • History of drug abuse
  • Currently taking cardiovascular (statins, beta-blockers) therapeutics and/or other medications that could influence the outcome measures

Recruiting US locations

  • Craig Hospital

    Englewood, CO 80113

    Site contact: Genevieve Madera, B.S. · 7203454640 · Gmadera@craighospital.org

Study contacts (from the official record)

  • Genevieve Madera, BS · 17203454640 · Gmadera@craighospital.org
  • Clare Morey, SLP-CCC · 303.789. 8621 · Gquintero@craighospital.org
All healthy volunteers studies in Colorado →
Endothelial Dysfunction After SCI (NCT07227727) | Bored Studies