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Ethanol Induces Skeletal Muscle Autophagy

The Cleveland Clinic · NCT03209791

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
40
US sites recruiting
1
Study start
May 18, 2015
Record last updated
January 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.

Being studied: Biopsies

Conditions: Alcoholic Liver Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Alcoholic liver disease

  • clinical, biochemical, imaging criteria and liver biopsy where available
  • Age 18 - 65 years old

Controls

  • Serum liver transaminases (i.e. ALT and AST) 40 IU/L
  • Normal liver ultrasound
  • Age 18 - 65 years old

Exclusion Criteria

For both groups - alcoholic liver disease and controls:

  • Poorly controlled diabetes mellitus (HbA1C>9.5 g/dl)
  • Untreated Hyper- / hypo- thyroidism
  • Patients on dialysis, renal disease with serum creatinine 1.5 mg/dL
  • Active intravenous drug use
  • History of bowel surgery or gastric bypass surgery
  • Medications known to alter muscle protein metabolism (i.e. corticosteroids, tamoxifen, high-dose estrogen, testosterone or anabolic steroids)
  • Metastatic disease, Advanced cardiac or pulmonary disease
  • Pregnancy
  • Coagulopathy- INR >1.4 and platelet count \<80,000/ml.

Recruiting US locations

  • Cleveland Clinic

    Cleveland, OH 44195

    Site contact: Revathi Penumatsa · 216-445-0688 · penumar@ccf.org

Study contacts (from the official record)

  • Revathi Penumatsa, MPH · 2164450688 · penumar@ccf.org
  • Annette Bellar, MSLA · 2166365247 · bellara@ccf.org
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Ethanol Induces Skeletal Muscle Autophagy (NCT03209791) | Bored Studies