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RecruitingAccepts healthy volunteersPhase 2

Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

Johns Hopkins University · with The Richman Family Precision Medicine Center of Excellence in Alzheimer Disease · NCT04765137

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 60–95 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
20
US sites recruiting
1
Study start
May 21, 2021
Record last updated
July 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.

Being studied: Atorvastatin Oral Tablet

Conditions: Mild Cognitive Impairment

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria are chosen to include participants with MCI, enriched for vascular risk factors:

  • MCI defined by Clinical Dementia Rating (CDR) of 0.5 or 1.0.
  • Memory, processing speed, executive function, language - cognitive scores > 1.5 standard deviations below age-education norms.
  • Not demented by history.
  • Not taking statins currently or in the last 6 months.
  • Cognitive/functional impairment not likely due to another neurological disease or delirium.

Exclusion Criteria

  • Taking a statin currently or have taken a statin in the last 6 months.
  • Contraindications to taking a statin.
  • Transplant patient taking cyclosporine.
  • Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
  • Diagnosis of dementia by history.
  • Current diagnosis of substance abuse.
  • History of stroke or myocardial infarction in past 6 months.
  • History of HIV.

Recruiting US locations

  • Johns Hopkins University, Bayview Medical Center

    Baltimore, MD 21224

    Site contact: Samantha Horn · 410-550-9020 · shorn8@jhmi.edu

Study contacts (from the official record)

  • Samantha Horn · 410-550-9020 · shorn8@jhmi.edu
  • Ritu Agarwal · 410-550-9020 · ragarw19@jhmi.edu
All neurology studies in Maryland →
Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity… (NCT04765137) | Bored Studies