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Evaluating the Clinical Efficacy of Thulio vs. Holmium Laser Enucleation of the Prostate

Smita De · NCT07187180

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · Men only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
50
US sites recruiting
1
Study start
June 2, 2025
Record last updated
September 30, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Many consider laser enucleation of the prostate the new 'gold standard' for the surgical treatment of benign prostatic hyperplasia (BPH) due to its excellent outcomes, high success rates, and long-term efficacy. Holmium laser enucleation of the prostate (HoLEP) was the earliest form of prostate enucleation and is recommended by the American Urological Association (AUA), along with thulium laser enucleation of the prostate (ThuLEP), as size-independent techniques for the management of BPH with fewer complications than transurethral resection of the prostate (TURP). Further development of laser technology has additionally led to enucleation using pulsed-modulated (e.g. "Virtual Basket™" mode or MOSES™ mode) holmium lasers as well as the thulium fiber laser.

Being studied: holmium laser; pulsed thulium laser

Conditions: BPH With Symptomatic Lower Urinary Tract Symptoms; BPH With Urinary Obstruction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Understand and voluntarily sign an informed consent form.
  • Patients must be males with a prostate, at least 18 years of age
  • No prior prostate surgery

Exclusion Criteria

  • Unable/refuse to provide informed consent
  • Prior prostate surgery
  • Bladder stones that requiring lasering (small stone that can be removed whole is ok)
  • Unable to hold anticoagulants or antiplatelets per standard protocols for surgery and up to 1 week postop.

Recruiting US locations

  • Cleveland Clinic Main

    Cleveland, OH 44195

    Site contact: Iva Markovic · 216-636-9694 · markovi@ccf.org

Study contacts (from the official record)

  • Iva Markovic · 216-636-9694 · markovi@ccf.org
  • Smita De, MD, PHD · 216-445-4818 · des@ccf.org
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Evaluating the Clinical Efficacy of Thulio vs. Holmium Laser… (NCT07187180) | Bored Studies